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. 2018 Aug 31;10:3149–3158. doi: 10.2147/CMAR.S166942

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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Radiosensitivity effect of MeJ depended on the expression of AKR1C3.

Notes: (A) KY170R cells (highly expressing AKR1C3) incubated with 200 μmol/L MeJ for 24 h before radiation were more sensitive to radiation than their untreated counterparts. MeJ could enhance the radiation sensitivity of KY170R cells that highly expressed AKR1C3. (B) sh-KY170R cells (not or lowly expressing AKR1C3) incubated with 200 μmol/L MeJ for 24 h were equally resistant to radiation as their untreated counterparts. (C) The survival curves of sh-KY170R and KY170R cells incubated with or without MeJ.

Abbreviations: AKR1C3, aldo-keto reductase family 1 member 3; IR, irradiation; MeJ, methyl jasmonate.