Table 2.
Characteristics of studies included for the association between P16INK4a methylation and clinicopathological features of ovarian cancer
| Authors | Year | Country | Geographical location | Number of patients | Age (years)a | Tumor stage
|
Tumor grade
|
Histological subtype
|
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| I–II (M/n) | III–IV (M/n) | 1–2 (M/n) | 3 (M/n) | Serous (M/n) | Non-serous (M/n) | ||||||
| Bhagat et al20 | 2014 | India | Asia | 134 | 49.55±9.72 | 19/41 | 39/93 | 18/45 | 40/89 | 32/76 | 26/58 |
| Cuľbová et al38 | 2011 | Slovakia | Europe | 13 | 54.8 (34–74) | NA | NA | NA | NA | 2/6 | 3/7 |
| Shen et al25 | 2008 | China | Asia | 63 | 52.8 (33–76) | 4/22 | 9/41 | 6/36 | 7/27 | 7/34 | 6/29 |
| Yang et al41 | 2006 | Hong Kong | Asia | 49 | 48.8 (26–79) | 4/24 | 5/25 | 6/22 | 3/25 | 3/17 | 6/32 |
| Makarla et al29 | 2005 | USA | America | 23 | 51.5 (20–86) | NA | NA | NA | NA | 2/9 | 5/14 |
| Liu et al28 | 2005 | USA | America | 52 | 61.5±9.4 | NA | NA | 10/41 | 3/11 | NA | NA |
| Katsaros et al43 | 2004 | Italy | Europe | 249 | 57(19–82) | 22/68 | 68/152 | 26/75 | 64/141 | 40/86 | 50/141 |
| Hashiguchi et al44 | 2001 | Japan | Asia | 46 | NA | 4/21 | 2/20 | 7/33 | 0/13 | 2/14 | 5/32 |
| McCluskey et al47 | 1999 | USA | America | 29 | NA | NA | NA | NA | NA | 1/14 | 1/15 |
| Milde-Langosch et al48 | 1998 | Germany | Europe | 44 | NA | NA | NA | NA | NA | 3/11 | 13/33 |
Note:
a
Age data are presented as mean ± SD or median (IQR).
Abbreviations: M, methylated; n, number of patients in the group; NA, not available.