Table 3.
Meta-regression and subgroup analyses of P16INK4a methylation in comparison of cancer tissues vs normal tissues
| Stratified analysis | Number of studies | Pooled OR (95% CI)
|
Meta-regression
|
Heterogeneity
|
||
|---|---|---|---|---|---|---|
| Random | Fixed | P-value | I2 (%) | P-value | ||
| Publication year | 0.376 | |||||
| ≤2005 | 4 | 5.69 (0.42–76.14) | 2.17 (1.17–4.05) | 84 | 0.0003 | |
| >2005 | 6 | 4.71 (1.30–17.07) | 4.65 (2.32–9.30) | 56 | 0.05 | |
| Geographical location | 0.161 | |||||
| Asia | 6 | 7.85 (1.33–46.32) | 5.87 (2.70–12.78) | 70 | 0.005 | |
| America | 3 | 2.31 (0.24–22.01) | 1.15 (0.56–2.37) | 68 | 0.05 | |
| Africa | 1 | 6.10 (1.89–19.69) | 6.10 (1.89–19.69) | – | – | |
| Method | 0.651 | |||||
| MSP | 7 | 4.49 (0.97–20.64) | 2.33 (1.38–3.92) | 77 | 0.0003 | |
| Others | 3 | 6.79 (2.43–18.94) | 8.11 (2.93–22.40) | 0 | 0.57 | |
| Case sample size | 0.041 | |||||
| <50 | 4 | 17.21 (4.54–65.28) | 15.75 (4.05–61.34) | 0 | 0.58 | |
| ≥50 | 6 | 2.21 (1.33–3.67) | 2.74 (0.71–10.53) | 75 | 0.001 | |
Abbreviations: MSP, methylation-specific PCR; OR, odds ratio.