Table 4.

Methylation of P16^INK4a CpG sites on Illumina HumanMethylation 27 BeadChip from TCGA datasets

Probe (Illumina HumanMethylation 27)	CpG island location (chromosome: DNA range)	Normal tissue beta value (mean, n=12)	Tumor tissue beta value (mean, n=582)	Adjusted P-valuea	Pearson correlation coefficient	Adjusted P-valueb
cg00718440	9: 21983444–21986348	0.016	0.016	0.960249	0.194104	0.001719
cg03079681	9: 21983444–21986348	0.015	0.026	<0.000001	0.012972	1.0
cg07752420	9: 21958106–21958899	0.149	0.653	<0.000001	0.569887	<0.000001
cg09099744	9: 21958106–21958899	0.099	0.642	<0.000001	0.630768	<0.000001
cg10895543	9: 21958106–21958899	0.120	0.651	<0.000001	0.624147	<0.000001
cg11653709	9: 21958106–21958899	0.144	0.610	<0.000001	0.555400	<0.000001
cg12840719	9: 21958106–21958899	0.092	0.594	<0.000001	0.627484	<0.000001
cg13479669	9: 21983444–21986348	0.045	0.027	0.004226	–0.150891	0.0333435
cg26673943	9: 21983444–21986348	0.047	0.056	0.042428	–0.269361	<0.000001

Notes:

^aP-value of t-test of the difference between normal tissue beta value and tumor tissue beta value.

^bP-value of Pearson’s correlation between the tumor tissues beta value and CDKN2A expression (n=368).

Abbreviation: TCGA, The Cancer Genome Atlas.