Table 1.

Select Ongoing Studies of Early Diagnosis and/or Treatment of GDM

Study Name	Principal Investigator/Institution	Target Sample Size	Key Inclusion Criteria	Intervention	Primary Outcome(s)
Early Screen and Treatment for Gestational Diabetes NCT02377531	Alejandro R. Rodriguez/University of South Florida	1020	BMI†>30 kg/m2, 12–18 weeks gestation	2-step screening* and diagnosis at 12–18 weeks gestation followed by treatment if diagnosed	Composite perinatal morbidity
Pre-diabetes: can early INTervention improve pregnancy Outcome (PINTO) ACTRN12615000904572	Ruth Hughes/University of Otago	150	HbA1c+ at <14 weeks gestation of 5.9–6.4%	Blood sugar monitoring beginning at <14 weeks gestation and medication as required	Preeclampsia; neonatal composite outcome
Early Gestational Diabetes Screening in the Gravid Obese Woman (EGGO) NCT01864564	Lori M. Harper/University of Alabama at Birmingham	960	BMI†≥30 kg/m2, 14–18 weeks gestation, no prior cesarean-section	2-step screening* at 14–18 weeks gestation followed by treatment if diagnosed	Composite perinatal outcome
Treatment of Booking GDM (TOBOGM) ACTRN12616000924459	David Simmons/Western Sydney University	800	GDM by IADPSG criteria at <20 weeks gestation	Delayed GDM treatment (24–28 weeks); blinded	Pregnancy-induced hypertension; neonatal composite outcome

^†BMI=body mass index.

⁺HbA1c=hemoglobin A1c *2-step screening: 50 gram non-fasting glucose load screening test followed by a 100 gram oral glucose tolerance test for diagnosis. (1)