Figure 6. Clonal expansion observed in known oncogenes.

Individual gene plots indicating the location of all detected integrations within 2 oncogenes identified as containing substantially expanded clones (A) JAK2 and (B) SEPT9. Gene name is listed at top left for each group, and specific location on chromosome is highlighted by red box. The gene transcript is expanded below chromosome; each arrow indicates a unique IS, and arrow direction depicts orientation. Black arrows represent an IS found in 1 cell, and red arrows represent an IS found in 2 or more, with the number of clones detected noted next to each arrow. Circled red arrows indicate expanded clones over 5 cells. Blue lines at the bottom of each graph represent all known transcript variants of each gene.