Figure 9. Effects of trabeculation on kinetic energy and energy dissipation in the ventricle at 4 dpf.

(A) Gata1a MO injection reduced viscosity and WSS, resulting in a lower kinetic energy (KE) profile than in WT embryos during a cardiac cycle. However, the ErbB2 inhibition model, which reduces trabeculation, resulted in similarly high KE. (B) Both gata1a MO injection and ErbB2 inhibition reduced energy dissipation in the ventricle, compared with that in WT embryos. (C) Wea mutants, which lack the atrial contraction needed for initiation of trabeculation, had a profound reduction in KE. (D) Wea mutants also had a profound reduction in energy dissipation, associated with ventricular remodeling (Figure 2A).