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. 2018 Jul 12;3(13):e95948. doi: 10.1172/jci.insight.95948

Figure 4. Liver-specific Ttp-KO mice have increased peripheral tissue insulin sensitivity after high-fat diet.

Figure 4

(A–D) lsTtp-KO mice have improved insulin sensitivity in adipose tissue (A and B) and skeletal muscle (C and D) after 12 weeks of HFD compared with control mice, as assessed by phosphorylated AKT S473 (pAKT) to total AKT (tAKT) ratio after injection of insulin (0.0075 U/kg) or saline (n = 6–9). Representative Western blotting results are shown in A and C, and densitometry analyses are provided in B and D. (E) lsTtp-KO mice fed HFD have significantly lower insulin levels at baseline and during hyperinsulinemic-euglycemic clamp studies. Data are presented as mean ± SEM. *P < 0.05 by 2-tailed unpaired Student’s t test.