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. 2018 Apr 16;145(16):dev160614. doi: 10.1242/dev.160614

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Histological evaluation of patient testis sections. Immunohistochemical localization of γH2AX in paraffin-embedded testis sections of fertile men (f) and patients with meiotic maturation arrest reveal two types of meiotic prophase arrest patients: type I (I) and type II (II) meiotic arrest. Type I meiotic arrest patients display meiotic prophase arrest and disturbed γH2AX distribution and no XY-body formation, type II meiotic arrest patients display meiotic prophase arrest but normal γH2AX distribution and XY-body formation. Left-hand panels show a global overview of the γH2AX staining in different germ cell populations within the testis and the right-hand panels show higher magnification images of γH2AX staining in spermatocytes. Depicted are: Sertoli cells (Ser), elongated spermatids (ES), A_pale and A_dark spermatogonia, spermatocytes (SP) and apoptotic spermatocytes (arrows). Scale bars: 3 μm (left); 10 μm (right).