Table 4.
Estimates from various Mendelian randomization methods for the association between education and smoking cessation
Method | Beta coefficient | 95% CI | P-value |
---|---|---|---|
IVW MR | 0.651 | 0.352, 0.950 | 5.54 × 10−5 |
Weighted median MR | 0.600 | 0.160, 1.040 | 0.008 |
Weighted modal MR | 0.391 | −0.587, 1.369 | 0.433 |
MR Egger estimate | 0.415 | −0.741, 1.571 | 0.475 |
MR Egger intercept | 0.004 | −0.015, 0.022 | 0.673 |
Egger SIMEX estimate | 0.606 | −1.141, 2.353 | 0.500 |
Egger SIMEX intercept | 0.001 | −0.027, 0.029 | 0.946 |
Analysis of 41 278 individuals (SNP n = 57 out of a possible 74).