Table 5.
Infant blood concentrations for HCB pre- and postnatal exposure (3, 6, 12 and 24 months), estimated through pharmacokinetic modelling for lipophilic compounds (ng/g lipid)
| Measured concentrations |
Estimated HCB (ng/g lipid) |
||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCB (ng/g lipid) |
Birth |
3 months |
6 months |
12 months |
24 months |
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| Cohort | Matrix | n | P25 | Median | P75 | %<LOD | P25 | Median | P75 | P25 | Median | P75 | P25 | Median | P75 | P25 | Median | P75 | P25 | Median | P75 | ||||
| INUENDO-Greenland | MB | 189 | 34.1 | 60.5 | 105.9 | 0% | 30.4 | 56.3 | 94.8 | 55.0 | 102.0 | 170.0 | 57.4 | 113.8 | 191.5 | 62.0 | 111.1 | 232.8 | 54.8 | 97.9 | 203.9 | ||||
| INUENDO-Ukraine | MB | 161 | 77.8 | 100.9 | 145.0 | 0% | 65.5 | 86.3 | 127.7 | 113.4 | 145.2 | 223.4 | 112.4 | 169.0 | 277.8 | 108.1 | 188.1 | 273.6 | 96.1 | 166.7 | 240.6 | ||||
| FLEHS I | CB | 248 | 10.2 | 22.3 | 36.5 | 24.20% | 10.1 | 22.3 | 36.5 | 6.1 | 21.2 | 43.3 | 5.0 | 17.3 | 46.8 | 3.9 | 14.2 | 40.3 | 3.5 | 12.5 | 35.5 | ||||
| PELAGIE | CB | 188 | 5.4 | 11.1 | 17.3 | 21.2% | 5.4 | 11.1 | 17.3 | 3.1 | 7.3 | 19.1 | 2.2 | 6.0 | 17.0 | 1.8 | 5.1 | 15.0 | 1.7 | 4.6 | 13.5 | ||||
| PCB cohort | CB | 452 | 41.2 | 75.6 | 133.1 | 3.6% | 41.2 | 75.6 | 133.1 | 34.9 | 103.4 | 199.8 | 27.4 | 98.7 | 215.1 | 22.2 | 88.5 | 204.9 | 20.3 | 79.4 | 191.6 | ||||
| INMA-Menorca | CB | 251 | 234.1 | 310.0 | 457.5 | 11.6% | 234.1 | 310.0 | 457.5 | 136.5 | 447.3 | 678.0 | 95.7 | 451.3 | 692.2 | 73.6 | 364.1 | 588.6 | 64.6 | 316.0 | 514.9 | ||||
| INMA-Valencia | MB | 347 | 40.5 | 74.6 | 118.2 | 4.3% | 34.0 | 64.1 | 104.4 | 32.4 | 82.3 | 151.7 | 30.0 | 81.7 | 171.4 | 24.8 | 71.2 | 160.5 | 21.7 | 62.0 | 140.4 | ||||
| INMA-Sabadell | MB | 442 | 22.8 | 40.3 | 65.2 | 8.1% | 19.5 | 35.3 | 58.3 | 28.2 | 53.0 | 86.3 | 27.5 | 54.8 | 93.2 | 22.4 | 49.4 | 89.5 | 19.6 | 43.6 | 78.4 | ||||
| INMA-Gipuzkoa | MB | 276 | 22.1 | 35.2 | 57.3 | 8.4% | 18.3 | 30.8 | 49.3 | 27.8 | 45.2 | 84.1 | 23.3 | 52.8 | 89.8 | 19.3 | 50.5 | 94.4 | 16.7 | 44.7 | 83.3 | ||||
| HUMIS | BM | 1015 | 8.7 | 10.7 | 13.1 | 0% | 9.5 | 11.8 | 14.6 | 16.3 | 20.5 | 25.3 | 20.9 | 27.5 | 34.5 | 23.0 | 31.7 | 40.4 | 23.4 | 34.2 | 46.0 | ||||
| DUISBURG | MB | 112 | 21.0 | 27.0 | 39.0 | 0% | 18.1 | 23.9 | 34.8 | 28.9 | 39.0 | 58.0 | 34.2 | 48.6 | 76.6 | 34.4 | 65.2 | 94.0 | 30.4 | 61.0 | 91.7 | ||||
MB: maternal blood; CB: cord blood; BM: breast milk; LOD: Limit of Detection; P25: 25th percentile; P75: 75th percentile.