Table 2.

The Lothian Birth Cohort of 1936 (LBC1936)

Variable measured	Wave 1	Wave 2	Wave 3	Wave 4	Wave 5a
	2004–07	2007–10	2011–13	2014–17	2017–19
	69.5 years (SD = 0.8)	72.5 years (SD = 0.7)	76.3 years (SD = 0.7)	79.3 years (SD = 0.6)	∼82 years
	N (m/f) = 1091	N (m/f) = 866	N (m/f) = 697	N (m/f) = 550	N = ∼440
	(548/543)	(448/418)	(360/337)	(275/275)
Cognitive ability
Moray House Test No. 12
Cognitive test battery
‘Frontal’ function tests (sub-sample n = 90)
Test of Premorbid Functioning, Trail Making Test (Part B)
Raven’s Progressive Matrices
Financial literacy and competence
Social and demographic data
Various including: age, marital status, residence
Various including: deprivation, education, occupation, retirement
Current employment status, volunteering and caring
Questionnaires
Various including: personality, quality of life, social support
Various including: personality, loneliness
Physical activity level, sport/exercise, intellectual/social activities
Food Frequency Questionnaire
Various including: social support, satisfaction with life, well-being
Sense of coherence, personal and social well-being
Attitudes to Ageing Questionnaire, health literacy, bilingualism
Various including: lifetime addresses, lifetime activity
The Brief Resilience Scale, self-reported memory problems
Sleep quality and pattern
Various including: apathy, sedentary patterns, social desirability
Musical experience and expertise
Physical and medical
Various including: smoking, alcohol, disease history, medication, height, weight, visual acuity, blood pressure, physical fitness
Self-rated health, dentition, stand tests
Head circumference, menopause
Ankle-brachial pressure index
Facial symmetry photographs
Salt intake, bioelectrical impedance analysis
Hearing
Incidence of falls
Sedentary behaviour analysis by electronic activity monitor
Biochemistry and haematology analysis
Various including: full blood count, coagulation, cholesterol
Various including: D-Dimer, eGFR, iron, urine analysis
Red cell folate
Urate
Sex hormone-binding globulin, testosterone
Free androgen index
International normalized ratio warfarin
Inflammation markers
High-sensitivity CRP, Von Willebrand Factor, interleukin 6
Various including: cystatin C, lipoprotein A, vitamin D
Oxidative stress
Urinary-8 isoprostane, trolox equivalent antioxidant capacity
DNA damage, antioxidant vitamins
Blood brain barrier
S100 beta
Saliva analysis
DNA (if unable to obtain blood sample only)
Cortisol (sub-sample n = 90)
Immunology
Cytomegalovirus (CMV) serostatus and titre
iPSC stem cell reprogramming
Peripheral blood mononuclear cell samples taken
Brain tissue analysis
Pre-mortem consent
Genetic analysis
Telomere length
Apolipoprotein E genotyping, genome-wide genotyping
DNA methylation
Transcriptome-wide gene expression
Whole-genome sequencing
Brain magnetic resonance imaging (MRI)
Various including: DT-tracts, volumes, atrophy/lesion rating
Whole brain structural connectome
Carotid Doppler ultrasound
Velocities, stenosis, intima-media thickness
Retinal imaging
Microvascular branching geometry, fractal dimension, tortuosity
Linkages
Date and cause of death, hospital discharge diagnosis
Dementia diagnosis
Medical prescription data

Participants of LBC1936 were originally tested on the Moray House Test No.12 intelligence test as part of the Scottish Mental Survey 1947 (N = 70 805) at a mean age of 10.9 years (SD = 0.3).

Table key

Data available:

= data available at previous cohort profile publication (2012).

= new data wave, repeat of previous variable.

= new variable not previously collected.

Forthcoming data:

= planned for Wave 5, repeat of previous variable.

= new variable forthcoming, not previously collected.

^aWave 5 in progress from October 2017: age and N are estimates based on attrition at previous waves.

CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; m/f, male/female.