Skip to main content
. 2018 May 17;11(6):392–401. doi: 10.1080/21541248.2018.1457914

Table 1.

Rab11 as an intrinsic regulator of axon growth and regeneration. This table consists of two sections demonstrating that Rab11 is important for axon growth and regeneration. The first section (grey, left columns) highlights the regeneration-associated proteins localised in Rab11-positive endosomes. The second section (white, right columns) summarises the main findings regarding axon growth and regeneration of the mentioned proteins. Studies that investigated neurite outgrowth in neuronal cell lines were excluded from this table.

Regeneration-associated proteins in Rab11-positive-endosomes References Main findings regarding axon growth and regeneration References
Rab11 (GTPase) Not applicable Expression enhanced the axon regeneration capacity of cortical neurons after in vitro laser axotomy Koseki et al., (2017)
Integrins Caswell et al., (2008); Expression of α9 integrin promoted dorsal root ganglia regeneration in rat Andrews et al., (2009); Cheah et al., (2017)
  Eva et al., (2010) Genetic deletion of α7 integrin impaired facial nerve regeneration in mice Werner et al., (2000)
    Genetic deletion of α7 integrin impaired sciatic nerve regeneration in mice Gardiner et al., (2005)
Insulin-like growth factor receptors (IGFRs) Romanelli et al., (2007) Function-blocking antibody of IGF-1R impaired axon outgrowth of corticospinal motor neuron in postnatal mice Ozdiner et al., (2006)
    In utero shRNA interference of IGF-1R impaired neuronal migration and axon formation in embryonic/postnatal mice Guil et al., (2017)
Reggies/flotillins Solis et al., (2013); Huelsbusch et al., (2015); Expression promoted retinal ganglion cells regeneration in rat Koch et al., (2013)
  Bodrikov et al., (2017) Morpholino interferences impaired retinal ganglion cells regeneration in zebrafish Munderloh et al., (2009)
Tropomyosin receptor kinase receptors (Trks) Ascaño et al., (2009); Expression of TrkB promoted corticospinal motor neuron regeneration after subcortical axotomy in rat Hollis et al., (2009)
  Lazo et al., (2013)