Table 2.

ARF6 as an intrinsic regulator of axon growth and regeneration. This table highlights the effects of ARF6 and its associated GAP and GEFs on axon growth and regeneration in vitro. Stimulation of anterograde transport of the axonal growth machinery promotes growth, while retrograde transport hinders growth.

ARF6 GEF/GAP	Main findings regarding axon growth and regeneration	References
ARF6 (GTPase)	Expression of wild type ARF6 inhibited axon growth by 30% in developing cortical neurons in vitro	Suzuki et al., (2010)
	Expression of wild type ARF6 or constitutively active ARF6 did not affect axon growth in developing hippocampus neurons in vitro	Hernandez-Deviez et al., (2004)
	Expression of dominant negative ARF6 increased axon growth by 100% in developing hippocampus neurons in vitro	Hernandez-Deviez et al., (2004)
	Expression of dominant negative ARF6 increased axon growth by 67% in developing cortical neurons in vitro	Suzuki et al., (2010)
ACAP1 (GAP)	Expression promoted axon growth by 25% in adult DRG neurons in vitro	Eva et al., (2012)
ARNO (GEF)	Expression of wild type ARNO inhibited axon growth by 50% in adult DRG neurons in vitro	Eva et al., (2012)
	Expression of wild type ARNO did not affect axon growth in developing hippocampus neurons in vitro	Hernandez-Deviez et al., (2004)
	Expression of catalytically inactive ARNO increased axon growth by 500% in developing hippocampus neurons in vitro	Hernandez-Deviez et al., (2004)
	Expression of catalytically inactive ARNO promoted axon growth by 30% in cortical neurons in vitro	Franssen et al., (2015)
EFA6 (GEF)	Expression inhibited axon growth by 50% in adult DRG neurons in vitro	Eva et al., (2012)
	Expression inhibited the axon regeneration capacity of adult DRG neurons by 70% after in vitro laser axotomy	Eva et al., (2017)
	shRNA interference increased the axon regeneration capacity of cortical neurons by 110% after in vitro laser axotomy	Eva et al., (2017)