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A potential bypassing pathway by glucocorticoid receptor (GR) upregulation leading to antiandrogen resistance. Blockade of androgen receptor (AR) by enzalutamide or abiraterone can lead to elevated GR expression which activates a subset of AR target genes as well as GR target genes causing tumor growth (red arrows). Combination with GR antagonist may overcome GR-driven resistance to antiandrogens.
