Table 3. Distribution of genotypes and odds ratios (OR) for different histological subtypes of thyroid carcinoma and controls.
Genotypes PARP1 |
Controls (n = 400) | Papillary carcinoma | *P- value | Follicular | *P- value | Medullary | *P- value | Anaplastic | *P- value | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | (n = 351) | n | carcinoma | n | carcinoma | n | (n = 7) | ||||||
OR (95% CI) | (n = 82) | (n = 16) | OR (95% CI) | ||||||||||
OR (95% CI) | OR (95% CI) | ||||||||||||
rs1136410 | |||||||||||||
TT | 93 | 64 | 1.00(Ref) | 15 | 1.00(Ref) | 3 | 1.00(Ref) | 4 | 1.00(Ref) | ||||
TC | 91 | 76 | 0.93(0.66–1.32) | 0.71 | 17 | 0.88(0.49–1.59) | 0.68 | 4 | 1.13(0.35–3.59) | 0.83 | 1 | 0.56(0.06–4.76) | 0.60 |
CC | 216 | 217 | 1.37(1.03- 1.84) | 0.02 | 48 | 1.20(0.74–1.94) | 0.45 | 9 | 1.09(0.40–2.99) | 0.85 | 2 | 0.340.06–1.77) | 0.207 |
rs1805414 | |||||||||||||
TT | 29 | 57 | 1.00(Ref) | 13 | 1.00(Ref) | 3 | 1.00(Ref) | 1 | 1.00(Ref) | ||||
TC | 291 | 209 | 0.55(0.40–0.74) | 0.0001 | 47 | 0.50(0.30–0.82) | 0.006 | 9 | 0.48(0.17–1.32) | 0.15 | 4 | 0.49 (0.11–2.26) | 0.36 |
CC | 80 | 91 | 1.40(0.99–1.97) | 0.05 | 20 | 1.29(0.73–2.25) | 0.37 | 4 | 1.33(0.41–4.24) | 0.62 | 2 | 1.60(0.30–8.39) | 0.57 |
rs1805404 | |||||||||||||
CC | 254 | 249 | 1.00(Ref) | 55 | 1.00(Ref) | 11 | 1.00(Ref) | 2 | 1.00(Ref) | ||||
CT | 98 | 86 | 1.00(0.71–1.39) | 0.99 | 18 | 0.86(0.48–1.53) | 0.62 | 4 | 1.02(0.32–3.25) | 0.96 | 1 | 0.51(0.06–4.31) | 0.53 |
TT | 48 | 22 | 0.49(0.28–0.83) | 0.008 | 7 | 0.68(0.29–1.57) | 0.37 | 01 | 0.48(0.06–3.78) | 0.49 | 4 | 9.77(2.12–45.0) | 0.003 |
OR, odds ratio; CI, confidence interval; OR, CI and *p-value calculated by regression analysis.