Table 2. Categorical time at target (TITRE), alternative measures of BP control and any cardiovascular disease.

Measures of BP control	Adjusted odds ratio (95% CI)
Binary	All CVD/death
Snapshot ‘control’ yes vs. no1	0.78 (0.76,0.81)
Control’ yes vs. no, defined with mean follow-up systolic blood pressure1	0.73 (0.71, 0.76)
Mean follow-up blood pressure1
Mean systolic blood pressure, per 7.5 mmHg decrease	0.83 (0.83, 0.85)
Mean diastolic blood pressure, per 5 mmHg decrease	0.93 (0.92, 0.94)
Blood pressure variability1,2
Standard deviation of systolic blood pressure, per 1 unit decrease	0.98 (0.98, 0.98)
TITRE1
0%	1.0 (Reference)
Missing	0.7 (0.64,0.77)
<3 months	0.58 (0.55,0.61)
3–5.9 months	0.40 (0.38,0.42)
6–8.9 months	0.27 (0.25,0.28)
9–11.9 months	0.17 (0.15,0.19)
TITRE1, With additional adjustment of systolic BP variability2
0%	1.0 (Reference)
Missing	N/A
<3 months	0.57 (0.54,0.6)
3–5.9 months	0.40 (0.38,0.43)
6–8.9 months	0.27 (0.25,0.29)
9–11.9 months	0.18 (0.16,0.2)
TITRE1, with additional adjustment of number of BP measures
0%	1.0 (Reference)
Missing	0.67 (0.62, 0.74)
<3 months	0.69 (0.65,0.72)
3–5.9 months	0.52 (0.49,0.55)
6–8.9 months	0.36 (0.34,0.38)
9–11.9 months	0.22 (0.2,0.25)

¹Adjusted for age, gender, year of study entry, multiple deprivation, ethnicity, BMI, smoking, history of diabetes, renal dysfunction, stage two hypertension, total cholesterol, statin use, aspirin use, initial blood pressure lowing drug type, dietary advice, smoking cessation, snapshot ‘control’ status (except for models with binary BP control measures).

²blood pressure variability was measured by the standard deviation of follow-up blood pressure measures of each patient.