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. 2018 Aug 30;11:5269–5278. doi: 10.2147/OTT.S168654

Figure 2.

Figure 2

Knockdown of SOX2OT inhibits NSCLC cell migration, invasion, and EMT process.

Notes: (A) Cell migration was examined by wound healing assay in A549 and H1299 cells transfected with nontargeting sequences (sh-NC) or short-hairpin RNA against SOX2OT (sh-SOX2OT). (B) Cell invasion was examined by Transwell invasion assay in A549 and H1299 cells transfected with sh-NC or sh-SOX2OT. (C) E-cadherin, N-cadherin, and vimentin levels were determined in A549 and H1299 cells transfected with sh-NC or sh-SOX2OT. *P<0.05 and **P<0.01.

Abbreviations: EMT, epithelial–mesenchymal transition; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; NSCLC, non-small-cell lung cancer; SOX2OT, Sox2 overlapping transcript.