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. 2018 Aug 30;11:5269–5278. doi: 10.2147/OTT.S168654

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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SOX2OT controls ZEB2 expression by regulating miR-132 in NSCLC cells.

Notes: ZEB2 expression on mRNA (A) and protein (B) levels were measured in A549 and H1299 cells transfected with nontargeting sequences (sh-NC), short-hairpin RNA against SOX2OT (sh-SOX2OT), and sh-SOX2OT + miR-132 inhibitor. (C) The relationship between SOX2OT expression and miR-132 expression in NSCLC samples (n=48). (D) The relationship between SOX2OT expression and ZEB2 mRNA expression in NSCLC samples (n=48). *P<0.05 and **P<0.01.

Abbreviations: GAPDH, glyceraldehyde 3-phosphate dehydrogenase; mRNA, messenger RNA; miR-132, microRNA 132; NSCLC, non-small-cell lung cancer; SOX2OT, Sox2 overlapping transcript; ZEB2, zinc finger E-box-binding homeobox 2.