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. 2018 Aug 30;10:3109–3123. doi: 10.2147/CMAR.S165980

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© 2018 Belykh et al. This work is published and licensed by Dove Medical Press Limited

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Images of a human glioblastoma multiforme. (A) Single-frame CLE image from the Z-stack. (B) Volumetric view with nuclei pseudocolored in blue, cytoplasm in red, and fluorescein diffusion in the tissue in yellow. (C) H&E-stained section of the same specimen showing the typical palisading pattern of a glioblastoma. Abnormally big contours of the neoplastic cells are visible on the right part of CLE images and are even better represented in the 3D rendering of the Z-stack.

Note: Used with permission from Barrow Neurological Institute.

Abbreviations: 3D, three-dimensional; CLE, confocal laser endomicroscopy; H&E, hematoxylin and eosin.