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. 2018 Aug 30;11:5303–5313. doi: 10.2147/OTT.S174103

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© 2018 Feng et al. This work is published and licensed by Dove Medical Press Limited

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Copy number variation results in the high expression of the E2F3 gene and affects prognosis.

Notes: (A) COSMIC shows that E2F3 variations in solid cancer are dominated by CNV gains and overexpression. (B) The E2F3 gene shows an increased expression level in patients with high E2F3 copy number (unpaired t-test, *P<0.0001). (C) The expression of the E2F3 gene is significantly positively correlated with the CNV level. (D) The copy number of the E2F3 gene affects the OS of 357 melanoma patients. (E) The copy number of the E2F3 gene affects the DFS of 315 melanoma patients.

Abbreviations: CNV, copy number variation; COSMIC, catalog of cancer somatic mutations; DFS, disease-free survival; OS, overall survival.