Fig 6. Effect of trypanocidal drugs on the infection of mice with Trypanosoma cruzi.

Mice were inoculated with 10² AR-SE23C or 10⁶ BOL-FC10A trypomastigotes and treated with BZ (40 doses of 100 mg/kg/d), NX (40 doses of 100 mg/kg/d) or PENT (20 doses of 4 mg/kg/d). Parasitemia curves in mice infected with AR-SE23C (A) and BOL-FC10A (B). (C) Parasitemia AUC in infected mice treated with PENT. **p<0.01 vs. non-treated infected controls; t-test. (D) Effect of treatment on survival rate of mice infected with AR-SE23C; **p<0.01 vs. non-treated infected controls; Mantel-Cox test.