Table 4. Trypanosoma cruzi DNA in blood of mice infected with AR-SE23C or BOL FC10A parasites and treated with benznidazole, nifurtimox or pentamidine.
| Treatment | Mice positive/ total (range Eq parasites/mL) | |
|---|---|---|
| AR-SE23C | BOL-FC10A | |
| Non-treated infected control | 3/4 (0,15–20,78) | 5/5 (90.80–429.0)§ |
| Benznidazole | 2/5 (0,29–46,34) | 0/5* |
| Nifurtimox | 5/5 (0.77–9.11) | 0/5* |
| Pentamidine | 1/5* (22.20) | 3/5 (262.20–527.0) |
Quantitative T. cruzi DNA amplification was performed at 70 dpi in all groups of mice. Data represent the number of mice with positive T. cruzi qPCR / total number of mice tested and (range of parasite DNA load in mice with positive qPCR).
*p<0.05 vs. non-treated infected controls; Fisher’s exact test.
§p<0.05 vs. non-treated AR-SE23C infected controls; Mann-Whitney test.