Table 2.

Melatonin (3–5 mg/day) vs. placebo in adults with bipolar disorders or schizophrenia (concomitant antipsychotic treatment: quetiapine and risperidone)

Outcome or subgroup	Study (n)	Participant (n)	Effect estimate
1.1 Body weight	2	80	−0.56 [−5.55, 4.44]
1.2 Body mass index	2	80	−0.23 [−1.90, 1.43]
1.3 Waist circumference	2	80	0.15 [−5.44, 5.73]
1.4 Hip circumference	2	80	−0.79 [−2.86, 1.28]
1.5 Total cholesterol	2	80	−4.23 [−38.96, 30.50]
1.6 LDL cholesterol	2	80	5.30 [−22.18, 32.78]
1.7 HDL cholesterol	2	80	1.72 [−1.78, 5.21]
1.8 Trigylcerides	2	80	−30.09 [−67.92, 7.73]
1.9 Fasting glucose	2	80	4.70 [−3.83, 13.23]

Statistical method: mean difference (inverse variance method, random, 95% confidence interval).

LDL, low-density lipoprotein; HDL, high-density lipoprotein.