Fig. 1.

(A) The visual image induced craving for ethanol (VICE) functional magnetic resonance imaging paradigm was presented in a block design, consisting of four 90-second epochs. The active blocks, alcohol-related cues (ARC; block ‘A’) and neutral cues (NC; block ‘N’), had 5 images which stayed on screen for 6 seconds. The resting control block (R) was a blank screen with fixation cross-hair. (B) Changes in the in-scanner craving responses (mean and standard error) averaged across subjects for different ARC exposure blocks for the baseline (solid lines) and 2nd week (dashed lines) scans shown for baclofen and control groups separately. For illustration each ARC block (liquor storefront, alcohol bottles, pouring and sipping alcohol) was scored 1 if the subjects experienced craving for alcohol (indicated by means of button presses) for at least two of the five cues in the block.