Fig. 2.

Brain regions depicting significant group-by-time interactions for alcohol vs. neutral cues thresholded at cluster p<0.05 family-wise error, whole-brain corrected. The results indicate significant activation of bilateral dorsolateral prefrontal cortex (DLPFC) and right anterior cingulate cortex (ACC) following baclofen treatment compared to the control group. Color-bar is indicative of z-values. For illustration of the group-by-time effects, mean (95% confidence inverval) beta weights from baclofen (circle, solid line) and control (triangle, dashed lines) groups were extracted using a 10 mm-radius sphere centered around the peak voxel at (B) ACC and (C) DLPFC and the change was plotted using an interaction plot. L, left; R, right.