Skip to main content
. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: ACS Chem Neurosci. 2018 Jun 20;9(8):2001–2008. doi: 10.1021/acschemneuro.8b00089

Figure 2.

Figure 2.

Stimulus parameters applied to the ON to induce temporal phase shifting and peptide release in the SCN and outcomes. (A) Three different 5-min electrical stimulation paradigms were utilized: Orange, 1 V, 10 Hz, 0.2 ms pulse duration; Green, 5 V, 5 Hz, 1 ms pulse duration; Purple, 5 V, 20 Hz, 1 ms pulse duration. (B) These three stimulation parameters at distinct temporal windows caused different patterns of peptide release (■), and phase shifts of a delay of ~ 2 hr (φD), advance of ~2–3 hr (φA), or an advance of ~ 6 hr (φA+), respectively. N.R., no releasate measured.