. Author manuscript; available in PMC: 2019 Sep 1.

Published in final edited form as: Cancer Res. 2018 Jul 16;78(17):4865–4877. doi: 10.1158/0008-5472.CAN-17-3977

Table 1.

Loss-of-function CYP2C9 alleles *2 and *3 associate with improved survival in NSCLC patients. Collapsed CYP2C9*2/*3 was associated with improved survival when adjusted for NSCLC stage, resection, and chemotherapy. To adjust for the effect of sex, sex was added to the model and a stratified Cox proportional hazard model was used. The sex stratified Cox proportional hazard models indicated the association of collapsed CYP2C9*2/*3 with NSCLC survival is limited to women.

Collapsed CYP2C92 or 3 model	HR	95% CI	p-value
No sex adjustment	0.644	0.417–0.994	0.047
Sex adjusted	0.675	0.437–1.044	0.077
Within men only	0.854	0.516–1.412	0.538
Within women only	0.383	0.157–0.935	0.035