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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: J Immunol. 2018 Jul 27;201(6):1717–1726. doi: 10.4049/jimmunol.1701241

Figure 2. CBLB constrains anti-fungal CD8+ T cell responses.

Figure 2.

Naïve Cblb+/+, Cblb+/− and Cblb−/− mice were vaccinated s.c. with the live attenuated strain #55 of B. dermatitidis (105 cfu). On day 16, dLNs and spleens were harvested and cytokine-producing CD8+ T cells were analyzed by flow cytometry. (A) CBLB expression (MFI) in naïve (CD44lo) and activated (CD44hi) CD8+ T cells on indicated days post-vaccination. Frequency (B) and numbers (C) of cytokine-producing cells gated on activated (CD44hi) CD8+ T cells. Values are mean ± SD. N=4 mice/group. *p≤0.05. Data is representative of two independent experiments. CD4+ T cells were depleted throughout the experiment.