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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: J Immunol. 2018 Jul 27;201(6):1717–1726. doi: 10.4049/jimmunol.1701241

Figure 4. CBLB regulates vaccine-immunity to inactivated fungal yeast.

Figure 4.

Naïve Cblb+/+ and Cblb−/− were vaccinated with 105 cfu of heat-killed (h.k) strain #55 yeast. (A) After a month rest, mice were challenged i.t. with a lethal dose (104 cfu) of virulent strain #26199. When unvaccinated mice were moribund (D16 post-infection; p.i.), lungs were harvested to quantify fungal burdens. CFUs are shown in whisker plots. N=4–14 mice/group. (B) Mice were vaccinated with killed yeast as above. Mice were challenged after 2 months rest and lungs were harvested (D4 p.i.) to enumerate cytokine-producing CD8+ T cells. N=2–4 mice/group. Data is representative of two independent experiments. *p≤0.05.