Table 2.
Infections pre- and post-aDLI
| Patient | aDLI dose/day |
CMV IgG (D/R) |
Pre-aDLI | Post-aDLI | |||||
|---|---|---|---|---|---|---|---|---|---|
| Bacterial Infection | Viral Reactivation | Viral Infn | Fungal Infn | Viral Reactivation | Viral Infn | Fungal Infn | |||
| 001 | Level 1, D+35 | −/− | None | None | None | None | VZV skin D+76 | None | None |
| 002 | Level 1, D+35 | +/− | Stomatococcua blood D+1 | BK urine D-8 | None | None | EBV blood D+147,BK urine D+49,254,331, VZV skin D+260 | EBV D+147 VZV D+260 |
None |
| 003 | Level 1, D+35 | −/+ | E.Coli blood D-3 VRE blood D0 |
HSV oral D+28 CMV blood D+33 |
HSV D+28 | None | None | None | None |
| 004 | Level 1, D+42 | +/+ | Enterobact. blood D-6 Proteus Urine D+32 |
BK urine D+5, CMV blood D+26, RSV NP D+26 | RSV D+26 | None | EBV blood D+234 | None | None |
| 005 | Level 2, D+42 | +/+ | None | None | None | None | RSV NP D+209 | RSV D+209 | None |
| 010 | Level 2, D+34 | +/+ | Staph Epi blood D-8 | CMV blood D+20,30 | None | None | CMV blood D+74,84,96, HHV6 BM D+78 | None | None |
| 012 | Level 2, D+35 | −/+ | C.Diff colitis D-2 | CMV blood D+20 | None | None | None | None | None |
| 013 | None given† | −/+ | Stomatococcus + VRE blood D+11 | N/E | N/E | N/E | N/E | N/E | N/E |
| 025 | None given§ | +/+ | Corynebacterium blood D+27 | HSV nasal D+24 CMV blood D+27 |
HSV nasal D+24 | N/E | N/E | N/E | |
| 026 | Level 2, D+35 | −/+ | None | None | None | None | None | None | None |
| 027 | Level 2, D+42 | +/+ | None | CMV blood D+16 | None | Aspergillus BAL D+13 | CMV blood ends D+73 then reactivates D+209 | CMV retinitis D+114 to D+176 | None |
| 028 || | None Given | +/+ | Fusobact + α-haem strep blood D+11 | N/E | N/E | N/E | N/E | N/E | N/E |
| 030 | Level 2, D+42 | −/+ | Staph Epi blood D-1 | HSV oral D+35 | HSV oral | None | None | None | None |
| 033 | Level 2, D+35 | +/+ | None | BK urine D+13 | None | None | BK blood D+53, EBV blood D+137. CMV blood D+179 | None | None |
| 035 | Level 2, D+35 | +/+ | VRE blood D+3 | CMV blood D+23 | None | None | None | None | Presumed fungal pneumonia D+62 |
| 015 | Level 3, D+36 | +/− | α-haem strep blood D+1, C.Diff colitis D+8 | None | None | None | EBV blood D+124 | EBV D+124 | None |
| 016 | Level 3, D+35 | +/+ | α-haem strep blood D+1 | BK urine D+13, CMV blood D+27 | None | None | CMV blood D+106, cleared after D+141 | None | Aspergillus pneumonia D+172 |
| 018 | Level 3, D+35 | −/− | None | Adeno blood, urine, stool D+18 BK urine D+25 | Adenov. | None | Adenovirus (cleared by D+73) | None | None |
| 023 | Level 3, D+35 | +/+ | VRE Blood D+5 | CMV blood D+24 | None | None | BK blood D+76, Adenovirus urine, stool, sputum D+106 | None | Aspergillus in BAL D+96 |
Level 1, 103 CD3 T-cells/Kg, Level 2 104 CD3 T-cells/kg, Level 3, 105 CD3 T-cells/kg; D, donor; R, recipient; BKV, BK virus, VRE, vancomycin-resistant enterococcus; HSV, herpes simplex virus; RSV, respiratory syncytial virus; CMV, cytomegalovirus; C Diff, clostridium difficile; BAL; Bronch-alveolar lavage,
†
died D+32 of bacterial sepsis prior to infusion of aDLI.
§
Donor not able to donate.
||
non-engraftment followed by autologous reconstitutiion