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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Stem Cells. 2018 Jul 3;36(9):1393–1403. doi: 10.1002/stem.2853

Figure 7. MSC spheroids formed from preconditioned cells promote bone formation in a critical-sized orthotopic bone defect.

Figure 7

(A) Microcomputed tomography images at week 12 in the defect space with quantified (B) bone volume and (C) bone mineral density. (D) Torsional stiffness of explanted femurs at 12 weeks; n=3-5 per group. IND = individual (non-aggregated) MSCs; SPH = spheroids. Significance is denoted by alphabetical letterings; groups with no significance are linked by the same letters, while groups with significance do not share the same letters.