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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: J Immunol. 2018 Aug 1;201(6):1645–1650. doi: 10.4049/jimmunol.1800438

Figure 1: Distribution of intracellular bacilli in Il1r1−/− BMDM macrophage cultures.

Figure 1:

WT or Il1r1−/− BMDM were infected with H37Rv (MOI:1) Mtb in vitro. Number of acid fast bacilli per 503 WT and 1481 Il1r1−/− macrophages was assessed by microscopy on d5 pi. Data are pooled from 2 independent experiments. A Histogram plots from WT (white) and Il1r1−/− (black) BMDM B Proportion of uninfected macrophages (defined as 0 Mtb bacilli, left panel) and heavily infected (defined as 25 or more Mtb bacilli, right panel). P values were derived by 2×2 contingency table test. C Average Mtb burden within 1–24 range (Mann-Whitney test). D Quantile-quantile plot of Mtb distribution. Dotted lines indicate area of significant difference in the distributions. E Average Mtb burden for intermediate (10–20 bacilli) range (Mann-Whitney test).