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. Author manuscript; available in PMC: 2019 Sep 4.
Published in final edited form as: Structure. 2018 Jun 14;26(9):1275–1283.e3. doi: 10.1016/j.str.2018.05.005

Figure 4. Lattice contact created by a base-stacking interaction in mutant M3.

Figure 4

(A) Stereo view of the A-rich bulge (green) and J5/5a region of a symmetry-related molecule in the WT structure (red). (B) The M3 structure at 3.95 Å resolution shows that in molecule B inserted A185* and A186 take the approximate positions of A186 and A187 in the WT structure. Such a shift of register leads A187 to bulge out and produce new base stacking with the bulged A125 of a symmetry-related molecule A. Blue mesh shows 2Fo-Fc map contoured at 1.0 σ level.