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. 2018 Sep 5;6(17):e13841. doi: 10.14814/phy2.13841

Figure 1.

Figure 1

Gαi2 participates in the regulation of platelet cell membrane scrambling and platelet volume. (A–C) Original histogram overlays of the annexin‐V binding in platelets isolated from WT mice (blue shadow) and Gα i2‐deficient mice (black line) without (A) and with (B) a 10 min treatment with thrombin (0.01 U/mL) or (C) a 10 min treatment with collagen‐related peptide CoRP (5 μg/mL). (D) Arithmetic means ± SD (n = 4) of the annexin‐V binding in platelets isolated from WT mice (blue bar) and Gα i2‐deficient mice (black bar) prior to (control) and following a 10 min treatment with thrombin (0.01 U/mL) or a 10 min treatment with collagen‐related peptide CoRP (5 μg/mL). ### (P < 0.001) indicates statistically significant difference from absence of thrombin and CoRP, * (P < 0.05) and *** (P < 0.001) indicates statistically significant difference from WT mice. (E–G) Original histogram overlays of the forward scatter of platelets isolated from WT mice (blue shadow) and Gα i2‐deficient mice (black line) without (E) and with (F) a 10 min treatment with thrombin (0.01 U/mL) or (G) a 10 min treatment with collagen‐related peptide CoRP (5 μg/mL). (H) Arithmetic means ± SD (n = 4) of the forward scatter of platelets isolated from WT mice (blue bar) and Gα i2‐deficient mice (black bar) prior to (control) and following a 10 min treatment with thrombin (0.01 U/mL) or a 10 min treatment with collagen‐related peptide CoRP (5 μg/mL). ### (P < 0.001) indicates statistically significant difference from absence of thrombin and CoRP, * (P < 0.05) and *** (P < 0.001) indicates statistically significant difference from WT mice.