Fig. 8.

—A putative YY1 binding motif resides next to the CTCF motif at Sites-6 and Site-7. Sequence logos of ICCE CTCF Site-6 (top) and Site-7 (bottom) for different mammalian ICCE orthologs. The presence of an identical base at a particular location in a motif is represented by a single base, whereas variation between sites at a particular position in the motif shows two or more bases with relative frequency represented by the size of the height of the base. The human CTCF and YY1 consensus sequences were adapted from the sequence logo obtained from JASPAR (Khan et al. 2018). The corresponding bases for each binding motif are highlighted immediately beneath the logos by the red–gray (CTCF) or blue–gray (YY1) shading.