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. 2018 Sep 5;8:13258. doi: 10.1038/s41598-018-31312-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BAPN ameliorates the reduced vascular remodeling after carotid artery ligation. Left common carotid arteries were harvested from TgLOX mice and wild-type (WT) littermates treated or not with BAPN 21 days after permanent ligation. Morphometric analysis was performed as described in the Material and Methods section. (a) Representative microphotographs of injured carotid arteries stained with hematoxylin and eosin in these animals. Bar: 100 µm. (b) Analysis of the percentage of stenosis and intima and media areas from sections covering the region 1.4 to 1.6 mm from the ligation site. Three cross-sections for each carotid artery were measured, and the data were averaged. Data are expressed as mean ± SEM. P < 0.05: * vs. wild-type animals; ^# vs. TgLOX mice (Two-way ANOVA; at least n = 6).