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. 2018 Sep 6;9(9):178. doi: 10.1038/s41424-018-0044-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Prohibitin mRNA and protein expression were generally expressed in 8 pancreatic cancer cell lines with Real-Time PCR and western blot. AsPC-1 and MiaPaCa-2 cells were selected for further functional experiments due to their various PHB expression. β-actin was used as housekeeping. GAPDH was used as a loading control. b AsPC-1 and MiaPaCa-2 cells were transfected with control siRNA or PHB siRNA for 48 h, total proteins were extracted and western blotting analysis was performed, 59.6% and 87.1% PHB proteins were reduced, respectively. c The effects of siRNA-PHB on pancreatic cancer cells AsPC-1 and MiaPaCa-2, the growth after 24 h, 48 h and 72 h were assessed using CCK-8 assay (mean ± SD; *p < 0.05). d The migration of AsPC-1 and MiaPaCa-2 cells were assessed after siRNA-PHB transfection and compared with negative control transfected cells (mean ± SD; **p < 0.01). e The invasiveness of AsPC-1 and MiaPaCa-2 cells were assessed after siRNA-PHB transfection and compared with negative control transfected cells (mean ± SD; **p < 0.01)