Table 2.
Univariable and multivariable analysis of prognostic factors
| Univariable analysis | Multivariable analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Comparator | N | Median survival (95% CI) in months | Log-rank | p value | HR | 95% CI | p value | |
| Median age (years) | ≥65.5 vs. <65.5 | 23/43 | 18.2 (12.8–23.7) vs. 21.6 (16.6–26.6) | 0.291 | 0.508 | 1.811 | 0 0.307–0.791 | 0.325 |
| Gender | M/F | 35/31 | 18.9 (13.7–24.1) vs. 22.1 (16.8–27.4) | 0.575 | 0.239 | 1.158 | 0.297–1.463 | 0.589 |
| Tumour location | Head vs. body/tail |
42/24 | 22.5 (17.4–27.5) vs. 17.5 (11.7–23.4) | 0.436 | 0.174 | 0.976 | 0.398–1.324 | 0.435 |
| T-status | T1/T2 vs. T3/T4 |
11/55 | 29.2 (19.8–38.7) vs. 18.9 (14.8–23.1) | 0.194 | 0.097 | 1.576 | 0.12–2.312 | 0.292 |
| N-status | N0 vs. N1 | 30/36 | 25.6 (19.5–31.8) vs.16.2 (12.0–20.5) | 0.163 | 0.016 | 1.18 | 0.63–2.21 | 0.61 |
| TNM-stage | I/II/III/IV | 5/48/6/7 | 30.1 (22.4–37.6) vs.19.3 (15.3–23.3) vs.26.7 (13.5–39.8) vs.10.4 (2.7–18.2) |
0.114 | 0.025 | 1.12 | 0.53–2.36 | 0.76 |
| Grade | G1 vs. G2 vs. G3 | 9/28/29 | 37.2 (26.4–48.1) vs. 18.1 (13.4–22.9) vs.17.6 (12.4–22.7) |
0.51 | 0.021 | 1.67 | 1.07–2.61 | 0.026* |
| PHB score | ≤4 vs. >4 | 37/29 | 27.4 (9.4–12.9) vs. 11.1 (21.9–33.0) | 1.446 | 0.001 | 4.25 | 2.09–4.26 | 0.001** |
*p < 0.05, **p < 0.01