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. 2018 Sep 5;8:13236. doi: 10.1038/s41598-018-31653-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Patient classification performance in a real clinical setting. Four out of five approaches (GLM, SSM/PCA1, SVM-ISDA and SVM-SMO) achieved desirable performance (sensitivity × specificity >0.5) in classifying prodromal AD vs. stable MCI. Interestingly, >84% of DLB/PDD patients were also classified as “AD”, while low sample size limits definite conclusion on the cases of FTD and VaD.