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. 2018 Sep 5;8:13236. doi: 10.1038/s41598-018-31653-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AD-like glucose metabolic pattern expression in alphasynucleinopathy. As can be expected from Fig. 3, the majority of PDD (17 of 19) and DLB (14–15 of 19) patients were classified as AD, when analyzed by the SVM method. However the majority of non-demented PD (PDND; 15 of 17)) or PD patients with MCI (PD-MCI; 18–19 of 26) were not classified as AD. None of the healthy control subjects were classified as AD when SVM was used. When other methods (GLM and SSM/PCA) were used, the rate of AD designation was significantly higher in PD-MCI, PDND and NL, potentially suggesting false positive identification.