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. 2018 Aug 30;11:303. doi: 10.3389/fnmol.2018.00303

Figure 4.

Figure 4

Dopamine (DA) has no effect on homeostatic excitatory synaptic plasticity of GCs in 4-week-old slice cultures. (A) Sample traces of AMPA receptor-mediated mEPSCs recorded from immature and mature GCs of 4-week-old entorhino-hippocampal slice cultures in presence of DA-only or DA + TTX. (B) Group data of mEPSC recordings (amplitudes and frequencies) from immature and mature GCs of 4-week-old slice cultures cultures (immature: ncontrol = 7 cells, nTTX = 7 cells; mature: ncontrol = 17 cells, nTTX = 14 cells; Mann-Whitney test; U-values ≤49.5). (C) Sample traces of AMPA receptor-mediated mEPSC recorded from immature and mature GCs of 4-week-old entorhino-hippocampal slice cultures in presence of SCH23390 (D1/5 receptor antagonist) or SCH23390 + TTX. (D) Group data of mEPSC recordings (amplitudes and frequencies) from immature and mature GCs of 4-week-old slice cultures cultures (immature: ncontrol = 7 cells, nTTX = 7 cells; mature: ncontrol = 10 cells, nTTX = 10 cells; Mann-Whitney test; U-values ≤6). Individual data points are indicated by gray dots. Values represent mean ± SEM (**p < 0.01; ***p < 0.001; NS, non-significant difference).