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. 2018 Sep 5;8:13229. doi: 10.1038/s41598-018-31408-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ex-vivo immunostaining of single-perfused rat postcapillary venules demonstrate disruption of vinculin staining along the membrane after histamine stimulation. (A) In postcapillary venules actin forms longitudinal fiber bundles. (B) Endothelial cells display vinculin staining under resting conditions while the staining along cell borders is disturbed after stimulation with histamine (arrow). (C) Overlay of F-actin and vinculin staining (n = 4 independent experiments). (D) Co-localization between vinculin and actin, determined by Pearsons correlation coefficient, appears to be slightly reduced due to histamine treatment (n = 4 independent experiments).