. 2018 Sep 5;8:13255. doi: 10.1038/s41598-018-31564-6

Table 2.

Significantly changed proteins between 2D- and 3D-cultured SW480 cells upon treatment with XAV939.

Protein ID	Gene name	Protein name	GO terms			3D_XAV939/3D: 2D_XAV939/2D
Protein ID	Gene name	Protein name	Biological Process	Molecular Function		Log₂ ratio	P-value
Up-regulated proteins
P15428	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Lipid metabolism		Oxidoreductase	0.75	0.014
Q96HY7	DHTKD1	Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1	Metabolic process		Oxidoreductase	0.63	0.019
Q2TAP0	GOLGA7B	Golgin subfamily A member 7B	Protein transport		Transferase	0.49	0.035
O95487	SEC24B	Protein transport protein Sec24B	Protein transport		Protein/Metal ion binding	0.47	0.046
Q8NFZ8	CADM4	Cell adhesion molecule 4	Cell adhesion		Receptor binding	0.46	0.005
Q9Y570	PPME1	Protein phosphatase methylesterase 1	Protein modification		Hydrolase	0.46	0.021
P06396	GSN	Gelsolin	Cytoskeleton reorganization		Actin binding	0.39	0.001
Q86VP1	TAX1BP1	Tax1-binding protein 1	Apoptosis		Protein/Metal ion binding	0.39	0.012
Q8WVY7	UBLCP1	Ubiquitin-like domain-containing CTD phosphatase 1	Protein modification		Hydrolase	0.38	0.020
P06703	S100A6	Protein S100-A6	Signal transduction		Protein/Metal ion binding	0.38	0.011
Down-regulated proteins
Q6V1P9	DCHS2	Protocadherin-23	Cell adhesion		Metal ion binding	−1.79	0.008
Q9HD26	GOPC	Golgi-associated PDZ and coiled-coil motif-containing protein	Protein transport		Protein binding	−1.16	0.018
P05204	HMGN2	Non-histone chromosomal protein HMG-17	DNA replicatoin		DNA binding	−0.90	0.050
Q9UKX7	NUP50	Nuclear pore complex protein Nup50	Intracellular transport		Ran GTPase binding	−0.74	0.038
P49840	GSK3A	Glycogen synthase kinase-3 alpha	Wnt signaling pathway		Protein kinase	−0.53	0.001
P49841	GSK3B	Glycogen synthase kinase-3 beta	Wnt signaling pathway		Protein kinase	−0.49	0.001
O43913	ORC5	Origin recognition complex subunit 5	DNA replicatoin		DNA binding	−0.44	0.001
P00338	LDHA	L-lactate dehydrogenase A chain	Metabolic process		Oxidoreductase	−0.43	0.008
P35269	GTF2F1	General transcription factor IIF subunit 1	DNA transcription		DNA binding	−0.40	0.029
Q15291	RBBP5	Retinoblastoma-binding protein 5	DNA transcription		DNA binding	−0.40	0.010
P47895	ALDH1A3	Aldehyde dehydrogenase family 1 member A3	Metabolic process		Oxidativereductase	−0.40	0.002
P99999	CYCS	Cytochrome c	Metabolic process		Elctron transport	−0.40	0.001
Q15075	EEA1	Early endosome antigen 1	Protein transport		Lipid binding	−0.38	0.028
Q92688	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B	Chromatin remodeling/Apoptosis		Protein binding	−0.38	0.050

Notes: GO terms determined using PANTHER analysis tool. 3D_XAV939: 3D culture treated with XAV939, 3D:3D culture, 2D_XAV939: 2D culture treated with XAV939, 2D: 2D culture. Abbreviations: GO, Gene ontology.