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. 2018 Sep 5;8:13270. doi: 10.1038/s41598-018-31438-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a–c) Phylogenetic trees of OTUs from all 4 datasets identified as significant when comparing Control and MRF supplemented BCC. The orange circles represent OTUs that were more abundant in the MRF supplemented BCC, and blue circles represent OTUs that were less abundant in the MRF supplemented BCC. The size of the circles is directly proportional to the magnitude of the abundance. All of these OTUs were considered to be significant features by ERF. Panel a shows the order Bacteroidales OTUs with Coprococcus catus as the outgroup. Panel b shows the orders Clostridiales, Bifidobacteriales, and Bdellovibrionales with Lactobacillus salivarius as the outgroup. Panel c shows the orders Burkholderiales, Aeromonadales, Selenomonadales, Erysipelotrichales, Lactobacillales, and Kiloniellales with Coprobacillus cateniformis as the outgroup.