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. 2018 Aug 30;9:499. doi: 10.3389/fendo.2018.00499

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Copyright © 2018 Ding and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Common structure and biological function of IGFBPs. (A) The N-terminal region (blue) and the C-terminal region (yellow) are connected by a linker region (green). Both N-domain and C-domain contains a binding site for IGFs (orange). (B) The proteolysis of IGFBPs by various proteases (pink) occurs in the linker region or other post-translational modifications, may result in IGFs release. (C) Once released from IGFBPs, IGFs bind to IGF receptors (purple) to exert their physiological effects.