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. 2018 Aug 30;12:263. doi: 10.3389/fncel.2018.00263

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Copyright © 2018 Elamin, Ruskin, Masino and Sacchetti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of KD treatment on hippocampal PARP-1 levels and 8-OHdG levels. (A) Quantification of normalized PARP-1 protein levels in hippocampi obtained from animals fed standard chow (CD), or KD for 2d or 3w. Representative image of PARP-1 Western blot included. Each lane represents an individual animal. Blots were repeated 2–3 times. (B) Significant and progressive decrease in 8-OHdG levels was observed in hippocampi obtained from KD treated animals. CD, n = 6; 2d KD, n = 8; 3w KD, n = 8 (n = 2 for each animal).