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. 2018 Aug 30;9:1982. doi: 10.3389/fimmu.2018.01982

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Copyright © 2018 Bai, Wu, Chen, Wang, Li, Zhang, Wu, Cai and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological changes in glomeruli during each stage of rat Thy1.1 and murine Habu glomerulonephritis. (A) Periodic acid-Schiff (PAS)-stained tissues were examined during the time course of nephritis induced by anti-Thy l.1 antibody injections in rats. (B) PAS-stained tissues were examined during the time course of nephritis induced by Habu snake Trimeresurus flavoviridis injections in mice. (C) Glomerular cell proliferation, as shown by proliferating cell nuclear antigen (PCNA) staining, and histological analysis of PCNA-positive glomerular cells in kidney sections obtained from Thy1.1 and Habu GN models. (D) Quantification of PCNA-positive cells in glomeruli of MsGN models. Data are presented as the mean ± SEM (n = 10 per group). *P < 0.05, compared with the Con. Con: non-nephritic phosphate-buffered saline (PBS)-treated animals. Original magnification, × 400; Scale bar = 50 μm.