. 2018 Sep 5;8:13267. doi: 10.1038/s41598-018-31596-y

Table 8.

Differentially regulated annotated transcripts identified for the parabolic flight and sounding rocket campaign data sets.

gene name	probeset ID	19^th DLR PFC fold change		TEXUS-49 fold change
gene name	probeset ID	BL-PFC hyp-g vs 1 g IF	µg vs BL-PFC hyp-g	µg vs BL-TX hyp-g	BL-TX hyp-g vs H/W 1g GC
CAV1	AF172085	2.280	−1.727	1.955	−2.294
SEC14L3	BC069641	1.921	−1.393	1.914	−1.945
LOC646156	XM_933449	1.756	−1.403	2.228	−1.827
LRRN5	NM_006338	1.494	−1.375	1.961	−1.763
BCAM	BC050450	2.084	−1.594	1.673	−1.674
SPATA21	BC022039	1.722	−1.499	1.681	−1.657
ACRBP	NM_032489	1.676	−1.488	1.631	−1.530
FHAD1	XM_934885	1.667	−1.405	1.587	−1.522
RNF43	NM_017763	1.570	−1.480	1.956	−1.409
GPR45	NM_007227	1.653	−1.478	1.438	−1.389
CCDC25	NM_001031708	−1.395	1.318	−1.450	1.303
UVRAG	BC064837	−1.816	1.346	−1.526	1.351
MLSTD1	NM_018099	−1.802	1.319	−1.557	1.372
ATP6V1E1	NM_001039366	−1.789	1.688	−1.528	1.443
RPL4	NM_000968	−1.398	1.305	−1.366	1.453
ALKBH3	NM_139178	−1.966	1.508	−1.447	1.495
SKP2	NM_005983	−2.057	1.454	−1.515	1.497
ANAPC1	BC104902	−1.444	1.318	−1.707	1.524
KLHL12	NM_021633	−1.482	1.302	−1.638	1.530
LOC158345	XM_931828	−1.370	1.399	−1.339	1.543
C6orf120	NM_001029863	−1.531	1.333	−1.644	1.562
LOC643980	XM_928714	1.382	−1.386	−1.757	1.576
PFAAP5	BC010643	−2.302	1.663	−1.951	1.593
MRS2L	BC069009	−1.655	1.301	−1.623	1.618
RABGAP1L	AB019489	−2.690	1.464	−1.663	1.636
CLEC12A	BC063424	−2.134	1.863	−1.659	1.640
COX11	BC005895	−1.698	1.383	−2.020	1.641
RNF146	AK027558	−1.504	1.433	−1.840	1.656
SMC2L1	NM_006444	−1.736	1.448	−1.832	1.670
CACNA2D3	AF516696	−2.237	1.575	−1.457	1.679
SLFN11	BC052586	−1.628	1.382	−1.882	1.681
NUP88	NM_002532	−2.345	1.780	−1.722	1.701
CSTF3	NM_001033506	−2.306	1.691	−1.501	1.730
DKFZP686M0199	XM_932404	−2.119	1.619	−1.655	1.747
NUP205	NM_015135	−1.542	1.349	−1.450	1.757
XRN1	NM_019001	−1.737	1.333	−1.478	1.764
MASA	NM_021204	−1.651	1.394	−1.688	1.807
CCDC52	BC036951	−2.512	1.655	−1.821	1.842
VLDLR	NM_003383	−2.133	1.488	−1.740	1.849
LOC653198	XM_926455	−2.844	1.454	−1.759	1.876
C18orf25	NM_001008239	−1.888	1.361	−1.748	1.889
C11orf57	BC005403	−2.209	1.904	−1.827	1.936
LOC644305	XM_927477	−2.447	1.598	−1.886	1.973
PXMP3	BC005375	−1.856	1.305	−1.804	2.033
ZNF25	NM_145011	−1.713	1.372	−1.795	2.062
HEATR3	NM_017939	−2.295	1.627	−2.083	2.093
C14orf135	NM_022495	−2.186	1.455	−1.932	2.112
SLC35A1	AJ851889	−2.364	1.884	−1.897	2.162
SCYL2	NM_017988	−1.629	1.312	−1.737	2.177
ANKRD49	BC017798	−1.720	1.347	−1.610	2.315
CLPX	AL136922	−2.210	1.729	−1.614	2.400
FLJ20105	NM_001009954	−2.728	1.687	−1.942	2.462
CLK1	NM_001024646	−2.657	2.114	−1.858	2.785
FLJ20152	NM_001034850	−1.808	1.319	−1.906	3.105
CSTF2T	NM_015235	−2.424	1.505	−1.900	3.661
MCM10	NM_018518	−3.352	1.815	−2.109	3.887
ZNF550	BC034810	−2.594	1.597	−3.259	3.934

Comparison of the intersections of hyper- and microgravity-double-sensitive transcripts revealed 57 annotated transcripts differentially regulated in all conditions for the 19^th DLR parabolic flight and TEXUS-49 suborbital ballistic rocket campaigns. All transcripts were reversely regulated with respect to micro- and hypergravity conditions within the same platform. Positive sign: significantly up-regulated transcripts (p-value < 0.05, FC ≥ +1.3), negative sign: significantly down-regulated transcripts (p-value <0.05, FC ≤ −1.3). FCs are ratios between the averages of linear expression values. If the ratio is <1, FC is calculated as the negative reciprocal of the ratio.