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. 2018 Aug 15;109(9):2641–2650. doi: 10.1111/cas.13731

Figure 3.

Figure 3

Erasure of age‐related epigenetic marks during cellular reprogramming in vitro. Reprogramming factors induce a loss of somatic cell identity and acquisition of self‐renewing capacity, leading to the derivation of induced pluripotent stem cells (iPSCs). During reprogramming, cellular marks of senescence and aging, which include epigenetic alterations, can be erased in vitro